Microheterogeneity ("neurotypy") of neurofilament proteins.
نویسندگان
چکیده
منابع مشابه
Neurofilament Proteins in Brain Diseases
Neurofilaments are the main components of intermediate filaments in neurons, and are expressed under three different subunit proteins, NFL, NFM and NFH. Neurofilaments act with microtubules and microfilaments to form and maintain the neuronal structure and cell shape. Phosphorylation is the main post-translational modification of neurofilaments, which influences their polymerization and depolym...
متن کاملStudies on the biosynthesis of neurofilament proteins
To determine whether the triplet polypeptides of neurofilaments arise by degradation of precursor, we studied the biosynthesis of neurofilament polypeptides both in vivo and in cell-free systems. Neurofilament-enriched fractions and polyribosomes were prepared from the same rabbit spinal cord homogenates. At 1 h after intracisternal administration of [34S]methionine, radiolabeled neurofilament ...
متن کاملNeurofilament proteins in the postnatal rat
Francisco R. López Picón Dept. of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku. Finnish Graduate School of Neuroscience. Neurofilament proteins (NFs) are the major components of the intermediate filaments of the neuronal cytoskeleton. The three different NF proteins; the low (NF-L), medium (NF-M), and dendrites. NF proteins play an important rol...
متن کاملNeurofilament proteins in avian auditory hair cells.
The distribution of middle-weight neurofilament protein (NF-M), an intermediate filament of neurons, was examined in the developing and mature avian inner ear by using immunocytochemical techniques. NF-M was detected in auditory hair cells and VIIIth cranial nerve neurons. NF-M-positive hair cells are first detected at embryonic day 11 (E11) in superior hair cells in the mid-proximal (mid-frequ...
متن کاملNeurofilament protein abnormalities in PC12 cells: comparison with neurofilament proteins of normal cultured rat sympathetic neurons.
The studies described here characterize abnormalities in the expression of neurofilament (NF) proteins in a clonal rat pheochromocytoma (PC12) cell line as compared with normal NF proteins in cultured rat sympathetic neurons (RSNs). Cytoskeletal extracts from PC12 cells grown in the presence (PC12+ cells) or absence (PC12- cells) of nerve growth factor (NGF) and from RSNs grown in the presence ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1983
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.80.10.3101